Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice.

Quantitative assessment and characterization of visceral nociception and hyperalgesia in the mouse

Increased visceral pain responsiveness in female mice compared to male mice afer partial sciatic nerve ligation

Neuropathic pain which is a chronic pain causes hyperalgesia due to peripheralm nerve damage.the relation between neuropathic pain and hyperalgesia and the response to treatment in case of somatic and inflammatory pain have been investigated previuosly.however the response of visceral pain in peripheral neuropathy and the possible gender differences in visceral pain response and gender differnc...

Thalamic control of visceral nociception mediated by T-type Ca2+ channels.

Sensations from viscera, like fullness, easily become painful if the stimulus persists. Mice lacking alpha1G T-type Ca2+ channels show hyperalgesia to visceral pain. Thalamic infusion of a T-type blocker induced similar hyperalgesia in wild-type mice. In response to visceral pain, the ventroposterolateral thalamic neurons evokeda surge of single spikes, which then slowly decayed as T type-depen...

Visceral hyperalgesia caused by peptide YY deletion and Y2 receptor antagonism

Altered levels of colonic peptide YY (PYY) have been reported in patients suffering from functional and inflammatory bowel disorders. While the involvement of neuropeptide Y (NPY) and Y receptors in the regulation of nociception is well established, the physiological role of PYY in somatic and visceral pain is poorly understood. In this work, the role of PYY in pain sensitivity was evaluated us...

Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice.

The excitatory ion channel transient receptor potential ankyrin-1 (TRPA1) is prominently expressed by primary afferent neurons and is a mediator of inflammatory pain. Inflammatory agents can directly activate [e.g., hydroxynonenal (HNE), prostaglandin metabolites] or indirectly sensitize [e.g., agonists of protease-activated receptor (PAR(2))] TRPA1 to induce somatic pain and hyperalgesia. Howe...